Pain Suppression really shines in a PvP or Arena situation. No one likes to have their enemies healed, so healers are often "target #1" and focused on by many enemies at once. A common strategy for an opposing group is to all simultaneously blow their most powerful cooldowns and spells on the enemy's healer. To avoid being instantly knocked out of the game, a priest can pop this spell in an attempt to survive the onslaught. If used with any combination of [fear], [shield], or grenade, and heals it is possible to survive an otherwise hopeless situation. Hopefully, while the priest was the focus, enemies will have been destroyed or fairly weakened by teammates.