Below is a list of Items of Epic quality items that begin quests found within World of Warcraft.
Key to the focusing Iris - http://www.wowhead.com/item=44569/ Looted from Kel'thuzad, this is an item used to enable a character access to the level 80 Raid, the Eye, in which players fight Malygos. This item is still ingame but is no longer needed to access the eye as of patch 4.0.1
Heroic Key to the focusing Iris -http://www.wowhead.com/item=44577 Looted from Kel'thuzad in Naxxramas 25 Man, this is an item used to enable a character access to the level 80 Raid, the Eye, in which players fight Malygos. This item is still ingame but is no longer needed to access the eye as of patch 4.0.1
Battered Hilt of Quel'Delar -http://www.wowhead.com/item=50380 A random drop from Pit of Saron, Halls of Reflection and The Forge of Souls. This item begins the quest chain for the epic item Quel'Delar.
Warlords Deck -http://www.wowhead.com/item=19257 A deck that is collected to create the Legendary Darkmoon Card, the deck is collected by finding and creating smaller cards. ie. Ace of Portals.
Head of Nefarian- http://www.wowhead.com/item=19003 An item that drops from Nefarian in Blackwing Lair, when handed in it gives the buff Rallying Cry of the Dragonslayer to all players and NPC's in Orgrimmar or Stormwind depending on your faction. Aside the temporary buff, it also rewards the player with gold and an item.
Head of Onyxia http://www.wowhead.com/item=18423 A no longer available item that was looted from the level 60 instance of Onyxia, where upon players could collect the head and return it to their capital city for a reward, which returned armour.
Magtheridon's Head http://www.wowhead.com/item=32385 An item looted from Magtheridon's lair in Hellfire peninsula, the item is handed in at either faction respective forward base in hellfire; Thrallmar or Nethergarde Keep.
Reply code Alpha http://www.wowhead.com/item=46052 This item is dropped by Algalon in Ulduar, it is used to start a world event in Dalaran in which the player returning it is hailed as the saviour of Azeroth and has saved it from ultimate destruction.
Below is a collection of the Darkmoon Card Decks that begin Quests for their respective Darkmoon Card Trinkets. A darkmoon deck is a deck of cards that is collected to create the epic-trinket Darkmoon Card, the deck is collected by finding and creating smaller cards. ie. Ace of Portals.
Volcanic Deck http://www.wowhead.com/item=62021
Hurricane Deck http://www.wowhead.com/item=62045
Tsunami Deck http://www.wowhead.com/item=62044
Earthquake Deck http://www.wowhead.com/item=62046
Tiger deck http://mop.wowhead.com/item=79323
Crane Deck http://mop.wowhead.com/item=79325
Serpent Deck http://mop.wowhead.com/item=79326
Blessings Deck http://www.wowhead.com/item=31890
Undeath Deck http://www.wowhead.com/item=44294
Nobles Deck http://www.wowhead.com/item=44326
Prisms Deck http://www.wowhead.com/item=44259
Chaos Deck http://www.wowhead.com/item=44276
Furies Deck http://www.wowhead.com/item=31907
Lunacy Deck http://www.wowhead.com/item=31914
Beasts Deck http://www.wowhead.com/item=19228
Elemenatals Deck http://www.wowhead.com/item=19267
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