- Patch 5.3.0 (21-May-2013): Blood Plague no longer benefits from the damage increase granted by Tricks of the Trade.
- Patch 5.2.0 (5-Mar-2013): Blood Plague now deals 15% more damage.
- Patch 5.0.4 (28-August-2012): Minor update.
- Patch 3.3.3 (2010-03-23): Applying this disease can no longer separately trigger effects from weapons.
- Patch 3.2.0 (04-Aug-2009): Damage done increased by 15%.
- Patch 3.1.0 (14-Apr-2009): No longer removes heal over time effects. Plague Strike's damage increased quite a bit to compensate. Now lasts 15 seconds untalented. It was 12.