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Best in slot (also "best-in-slot"; usually shortened to "BiS") is a term meant to describe the very best item, enchant and/or gem available to a character for a specific slot. While there are differences in opinion there is usually a generally held idea of what is the BiS. This term is used by the twink community for things that are best for particular levels, while it usually refers to level cap things.
Best-in-slot slot gear can change from patch to patch and may only be correct if the underlying methods or theorycrafting used to determine the item's status is correct.